咨詢： （重慶） （貴陽） Anti-PAX6 antibody [AD2.38] (ab78545)抗轉(zhuǎn)錄因子Pax6抗體產(chǎn)品信息： - Product nameAnti-PAX6 antibody [AD2.38]See all PAX6 primary antibodies ...
- Description
Mouse monoclonal [AD2.38] to PAX6 - SpecificityThis antibody recognizes both products of the two major alternatively spliced forms.
- Tested applicationsIHC-Fr, Sandwich ELISA, IHC-P, Flow Cyt, ICC/IF, IHC-FoFr more details
- Species reactivity
Reacts with: Mouse, Human
Predicted to work with: Rat, Chicken - Immunogen
Recombinant full length protein Human PAX6
Properties Applications Our Abpromise guarantee covers the use of ab78545 in the following tested applications. The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user. | Application | Notes |
|---|
| IHC-Fr | IHC-Fr: Use at an assay dependent concentration. | | Sandwich ELISA | sELISA: Use a concentration of 5 µg/ml. Can be paired for Sandwich ELISA with Rabbit polyclonal to PAX6 (ab82510). For sandwich ELISA, use this antibody as Capture at 5 µg/ml with Rabbit polyclonal to PAX6 (ab82510) as Detection. | | IHC-P | IHC-P: Use at an assay dependent concentration. | | Flow Cyt | Flow Cyt: Use 1µg for 106 cells. | | ICC/IF | ICC/IF: Use at an assay dependent concentration. | | IHC-FoFr | IHC-FoFr: Use at an assay dependent concentration. |
Target - FunctionTranscription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.
- Tissue specificityFetal eye, brain, spinal cord and olfactory epithelium. Isoform 5a is less abundant than the PAX6 shorter form.
- Involvement in diseaseDefects in PAX6 are the cause of aniridia (AN) [MIM:106210]. A congenital, bilateral, panocular disorder characterized by complete absence of the iris or extreme iris hypoplasia. Aniridia is not just an isolated defect in iris development but it is associated with macular and optic nerve hypoplasia, cataract, corneal changes, nystagmus. Visual acuity is generally low but is unrelated to the degree of iris hypoplasia. Glaucoma is a secondary problem causing additional visual loss over time.
Defects in PAX6 are a cause of Peters anomaly (PAN) [MIM:604229]. Peters anomaly consists of a central corneal leukoma, absence of the posterior corneal stroma and Descemet membrane, and a variable degree of iris and lenticular attachments to the central aspect of the posterior cornea.
Defects in PAX6 are a cause of foveal hypoplasia (FOVHYP) [MIM:136520]. Foveal hypoplasia can be isolated or associated with presenile cataract. Inheritance is autosomal dominant.
Defects in PAX6 are a cause of keratitis hereditary (KERH) [MIM:148190]. An ocular disorder characterized by corneal opacification, recurrent stromal keratitis and vascularization.
Defects in PAX6 are a cause of coloboma ocular (COLO) [MIM:120200]; also known as uveoretinal coloboma or coloboma of iris, choroid and retina. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Severe colobomatous malformations may cause as much as 10% of the childhood blindness. The clinical presentation of ocular coloboma is variable. Some individuals may present with minimal defects in the anterior iris leaf without other ocular defects. More complex malformations create a combination of iris, uveoretinal and/or optic nerve defects without or with microphthalmia or even anophthalmia.
Defects in PAX6 are a cause of coloboma of optic nerve (COLON) [MIM:120430].
Defects in PAX6 are a cause of bilateral optic nerve hypoplasia (BONH) [MIM:165550]; also known as bilateral optic nerve aplasia. A congenital anomaly in which the optic disc appears abnormally small. It may be an isolated finding or part of a spectrum of anatomic and functional abnormalities that includes partial or complete agenesis of the septum pellucidum, other midline brain defects, cerebral anomalies, pituitary dysfunction, and structural abnormalities of the pituitary.
Defects in PAX6 are a cause of aniridia cerebellar ataxia and mental deficiency (ACAMD) [MIM:206700]; also known as Gillespie syndrome. A rare condition consisting of partial rudimentary iris, cerebellar impairment of the ability to perform coordinated voluntary movements, and mental retardation. - Sequence similaritiesBelongs to the paired homeobox family.
Contains 1 homeobox DNA-binding domain.
Contains 1 paired domain. - Developmental stageExpressed in the developing eye and brain.
- Post-translational
modificationsUbiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation. - Cellular localizationNucleus.
- Information by UniProt
Database links - Entrez Gene: 5080 Human
- Entrez Gene: 18508 Mouse
- Entrez Gene: 25509 Rat
- Omim: 607108 Human
- SwissProt: P47237 Chicken
- SwissProt: P26367 Human
- SwissProt: P63015 Mouse
- SwissProt: P63016 Rat
Alternative names - AN 2 antibody
- AN antibody
- AN2 antibody
Anti-PAX6 antibody [AD2.38] images ![Sandwich ELISA - Anti-PAX6 antibody [AD2.38] (ab78545)](http://a.abcam.com/ps/datasheet/images/78/ab78545/PAX6-Primary-antibodies-ab78545-3.jpg) Sandwich ELISA - Anti-PAX6 antibody [AD2.38] (ab78545) Standard Curve for Pax6; dilution range 1 pg/ml to 1 ug/ml using Capture Antibody Mouse monoclonal [AD2.38] to PAX6 (ab78545) at 5 ug/ml and Detector Antibody Rabbit polyclonal to PAX6 (ab82510) at 0.5 ug/ml. ![Immunohistochemistry (Frozen sections) - Anti-PAX6 antibody [AD2.38] (ab78545)](http://a.abcam.com/ps/datasheet/images/78/ab78545/PAX6-Primary-antibodies-ab78545-12.jpg) Immunohistochemistry (Frozen sections) - Anti-PAX6 antibody [AD2.38] (ab78545)This image is courtesy of an anonymous Abreview Immunohistochemical analysis of mouse brain tissue, staining PAX6 with ab78545.
Tissue was fixed with paraformaldehyde and blocked with 10% serum for 1 hour at room temperature; antigen retrieval was by NO. Samples were incubated with primary antibody (1/100 in PBST) for 12 hours at 4°C. An AlexaFluor®568-conjugated goat anti-mouse polyclonal IgG (1/1000) was used as the secondary antibody.
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Centrosome Marker100ul3996gamma Tubulin抗體一抗 Abcamab11322Mouse monoclonal [TUB-11] to epsilon Tubulin100ul3996epsilon Tubulin抗體一抗 Abcamab11323Mouse monoclonal [6-11B-1] to Tubulin （acetyl K40）100ul3996Tubulin抗體一抗 Abcamab11324Mouse monoclonal [B3] to Tubulin - Polyglutamylated100ul4274Tubulin抗體一抗 Abcamab11325Mouse monoclonal [TUB-1A2] to Tubulin100ul3996Tubulin抗體一抗 Abcamab11326Mouse monoclonal [100/2] to alpha Adaptin100ul3996alpha Adaptin抗體一抗 Abcamab11327Mouse monoclonal [100/1] to AP1+2 beta1 00ul3996beta 1/2 Adaptin抗體一抗 Abcamab11328Mouse monoclonal [100/3] to gamma Adaptin100ul3996gamma Adaptin抗體一抗 Abcamab11329Mouse monoclonal [AP180-I] to AP180100ul3996AP18抗體一抗 Abcamab1133Rabbit polyclonal to GABARAP100ul3996GABARAP抗體一抗 Abcam ab11905Rabbit polyclonal to RUNX350ul3996RUNX3hystemcell一抗 Abcam ab11906Rabbit polyclonal to RUNX2100ul3996RUNX2hystemcell一抗 Abcam ab11907Rabbit polyclonal to AP2 alpha+beta50ul3996AP2 alpha/betahystemcell一抗 Abcam ab11908Rabbit polyclonal to ATF250ug3996ATF2hystemcell一抗 Abcam ab11909Mouse monoclonal [70B1413] to ATF6 - ChIP Grade100ug3996ATF6hystemcell一抗 Abcam ab1191Rabbit polyclonal to Histone H3 （acetyl K18） - ChIP Grade100ug4418Histone H3hystemcell一抗 Abcam ab11910Rabbit polyclonal to BAF57/SMARCE150ul3996BAF57hystemcell一抗 Abcam ab11914Rabbit polyclonal to c-Jun500ul3996c-Junhystemcell一抗 Abcam ab11917Rabbit polyclonal to c-Myc50ul3996c-Mychystemcell一抗 Abcam ab11918Rabbit polyclonal to c-Rel50ul3996c-Relhystemcell一抗 Abcam ab11919Mouse monoclonal to Caspase 850ug3996Caspase 8hystemcell一抗 Abcam ab1192Rabbit polyclonal to PKC mu （phospho S916）100ul3996PKC muhystemcell一抗 Abcam ab11920Mouse monoclonal [70A1426] to Caspase 1450ug3996Caspase 14hystemcell一抗 Abcam ab11922Mouse monoclonal [82B514] to CREB50ug3996CREBhystemcell一抗 Abcam ab11924Rabbit polyclonal to CREB50ul3996CREBhystemcell一抗 Abcam ab11925Mouse monoclonal [C160] to Cyclin A50ul3996Cyclin Ahystemcell一抗 Abcam ab11926Mouse monoclonal [GNS1] to Cyclin B150ul3996Cyclin B1hystemcell一抗 Abcam ab11927Mouse monoclonal [97A1015] to D4 GDI50ug3996D4 GDIhystemcell一抗 Abcam ab11928Mouse monoclonal [42C617] to DAP350ug3996DAP3hystemcell一抗 Abcam ab11929Mouse monoclonal to DAP550ug3996DAP5hystemcell一抗 Abcam ab11930Mouse monoclonal [37A565] to DcR350ug3996DcR3hystemcell一抗 Abcam ab11931Mouse monoclonal [32A1380] to DR450ug3996DR4hystemcell一抗 Abcam ab11933Rabbit polyclonal to DR6100ul3885DR6hystemcell一抗 Abcam ab11934Mouse monoclonal [Flt-1/EWF] to VEGF Receptor 1100ug3996VEGF R1hystemcell一抗 Abcam ab11936Hamster monoclonal to Podoplanin/gp36100ug5029Podoplanin/gp36hystemcell一抗 Abcam ab11937Rabbit polyclonal to FGF basic100ug3996FGF basic,bFGFhystemcell一抗 Abcam ab11938Rabbit polyclonal to PLGF100ug3996PLGFhystemcell一抗 Abcam ab11939Rabbit polyclonal to VEGF Receptor 2100ug3996VEGF R2hystemcell一抗 Abcam ab1194Rabbit polyclonal to IRS1 （phospho S307）100ug3996IRS1hystemcell一抗 Abcam ab11941Rabbit polyclonal to PROX1100ug4418PROX1hystemcell一抗 Abcam ab11946Goat polyclonal to Histone H3 （di methyl K4） - ChIP Grade100ul3996Histone H3hystemcell一抗 Abcam ab11950Mouse monoclonal [KH129] to E2F150ul3996E2F1hystemcell一抗 Abcam ab11951Mouse monoclonal [WUF11] to E2F450ul3996E2F4hystemcell一抗 Abcam ab11952Mouse monoclonal [TFE61] to E2F6100ug3885E2F6hystemcell一抗 Abcam ab11952Mouse monoclonal [TFE61] to E2F650ul3996E2F6hystemcell一抗 Abcam ab11954Rabbit polyclonal to COUP TF1500ul3996COUP TF1hystemcell一抗 Abcam ab11956Rabbit polyclonal to E74 like factor 150ul3996E74 like factor 1hystemcell一抗 Abcam ab11957Rabbit polyclonal to ELK150ul3996ELK1hystemcell一抗 Abcam ab11959Mouse monoclonal [83B1138] to Fos B50ug3996Fos Bhystemcell一抗 Abcam ab11961Rabbit polyclonal to Fos B50ug3996Fos Bhystemcell一抗 Abcam ab11962Rabbit polyclonal to GAGA50ul3996GAGAhystemcell一抗 Abcam ab11963Rabbit polyclonal to GATA1 - ChIP Grade50ul4107GATA1hystemcell一抗 Abcam ab11965Mouse monoclonal [cl. 65] to HBP150ul3996HBP1hystemcell一抗 Abcam ab11966Rabbit polyclonal to HDAC150ug3996HDAC1hystemcell一抗 Abcam ab11967Rabbit polyclonal to HDAC350ug3996HDAC3hystemcell一抗 Abcam ab11968Rabbit polyclonal to HDAC450ug3996HDAC4hystemcell一抗 Abcam ab11969Rabbit polyclonal to HDAC550ug3996HDAC5hystemcell一抗 Abcam ab11970Rabbit polyclonal to HDAC650ug3996HDAC6hystemcell一抗 Abcam ab11971Mouse monoclonal [MA5-3-19] to HFH450ul3996HFH4hystemcell一抗 Abcam ab11973Rabbit polyclonal to HMGB250ul3996HMGB2hystemcell一抗 Abcam ab11974Rabbit polyclonal to HNF150ul3996HNF1hystemcell一抗 Abcam ab11975Rabbit polyclonal to FOXA350ul3996FOXA3hystemcell一抗 Abcam ab11979Rabbit polyclonal to IRF650ug3996IRF6hystemcell一抗 Abcam ab1198Mouse monoclonal [GA170] to Lambda Light chain （Phycoerythrin）500ul3996Lambda Light chainhystemcell一抗 Abcam ab11980Rabbit polyclonal to IRF750ug3996IRF7hystemcell一抗 Abcam ab11981Rabbit polyclonal to JunB50ul3996JunBhystemcell一抗 Abcam ab11982Rabbit polyclonal to JunD50ug3996JunDhystemcell一抗 Abcam ab11983Mouse monoclonal [88C570] to Livin50ug3996Livinhystemcell一抗 Abcam ab11984Rabbit polyclonal to MAX50ug3996MAXhystemcell一抗 Abcam ab11985Mouse monoclonal [28A1004] to MBD250ug3996MBD2hystemcell一抗 Abcam ab11986Rabbit polyclonal to Myogenin100ul3996Myogeninhystemcell一抗 Abcam ab11987Mouse monoclonal [cl.1C4] to Nab250ul3996Nab2hystemcell一抗 Abcam ab11988Rabbit polyclonal to NFIA - ChIP Grade150ul3996NF1Ahystemcell一抗 Abcam ab11989Rabbit polyclonal to NFIB/NF1B250ug3996NF1B2hystemcell一抗 Abcam ab1199Mouse monoclonal [BB12+EDU-2] to CD3+CD4 （Dual color: FITC+PE）500ul3996CD3/CD4hystemcell一抗 Abcam ab11990Rabbit polyclonal to NFYB50ug3996NFYBhystemcell一抗 Abcam ab11992Mouse monoclonal [PT2] to Oct250ul3996Oct2,hystemcell一抗 Abcam ab11994Mouse monoclonal [98A1071] to Osteoprotegerin50ug3996Osteoprotegerinhystemcell一抗 Abcam ab11995Mouse monoclonal [87C553] to p6350ug3996p63hystemcell一抗 Abcam ab11996Mouse monoclonal [5B429] to p73100ul3996p73hystemcell一抗 Abcam ab11997Mouse monoclonal [38C674] to p73 Delta N50ug3996p73 delta Nhystemcell一抗 Abcam ab11998Mouse monoclonal [SD9] to p10750ul3996p107hystemcell一抗 Abcam ab12000Rabbit polyclonal to PAX550ul3996PAX5hystemcell一抗 Abcam ab12001Rabbit polyclonal to PBX1500ul3996PBX1hystemcell一抗 Abcam ab12002Rabbit polyclonal to Pit150ul3996Pit1hystemcell一抗 Abcam ab12007Mouse monoclonal [79B1048] to RAD1850ug3996RAD18hystemcell一抗 Abcam ab12008Mouse monoclonal [9A725] to RANK50ug3996RANKhystemcell一抗 Abcam ab12010Rabbit polyclonal to Retinoic Acid Receptor beta50ul3996Retinoic Acid Receptor betahystemcell一抗 Abcam ab12011Rabbit polyclonal to Retinoic Acid Receptor beta 250ul3996Retinoic Acid Receptor beta 2hystemcell一抗 Abcam ab12012Rabbit polyclonal to Retinoic Acid Receptor gamma50ul3996Retinoic Acid Receptor gammahystemcell一抗 Abcam ab12013Rabbit polyclonal to Rel B50ul3996Rel Bhystemcell一抗 Abcam ab12014Rabbit polyclonal to Retinoid X Receptor alpha100ul3996Retinoid X Receptor alphahystemcell一抗 Abcam ab12015Rabbit polyclonal to Retinoid X Receptor beta50ul3996Retinoid X Receptor betahystemcell一抗 Abcam ab12029Mouse monoclonal [HAP46.5] to HMGB1100ul4274HMGB1hystemcell一抗 Abcam ab12030Rabbit polyclonal to ELAVL2100ug3996ELAVL2hystemcell一抗 Abcam ab12030Rabbit polyclonal to ELAVL250ug3996ELAVL2hystemcell一抗 Abcam ab12034Mouse monoclonal [REMB1] to LEF150ug3885LEF1hystemcell一抗 Abcam ab12035Mouse monoclonal [REMB6] to LEF150ug3996LEF1hystemcell一抗 Abcam ab12036Sheep polyclonal to LEF150ug3996LEF1hystemcell一抗 Abcam ab12037Mouse monoclonal [3A12] to LEF150ug3996LEF1hystemcell一抗 Abcam ab12038Mouse monoclonal [1C3] to LEF150ug3996LEF1hystemcell一抗 Abcam ab12039Mouse monoclonal [C5] to MiTF50ug4218MiTFhystemcell一抗 Abcam ab12047Rabbit polyclonal to PHOX2B50ug3996PHOX2Bhystemcell一抗 Abcam ab1206Rabbit polyclonal to 6X His tag® （FITC）250ug3996His Taghystemcell一抗 Abcam ab12065Mouse monoclonal [6F12-3] to T Cell Factor 3+425ug3996T Cell Factor 3/4hystemcell一抗 Abcam ab12073Rabbit polyclonal to SUZ12 - ChIP Grade100ug4418SUZ12hystemcell一抗 Abcam ab12074Mouse monoclonal [AX 15] to KAT13B/AIB150ul3996NCOA3hystemcell一抗 Abcam ab12075Rabbit polyclonal to FOXO450ul3996FOXO4hystemcell一抗 Abcam ab12077Mouse monoclonal [27B2] to Desmoglein 150ug3996Desmoglein 1hystemcell一抗 Abcam ab12079Goat polyclonal to Histone H3 - ChIP Grade100ug3996Histone H3hystemcell一抗 Abcam ab1208Rabbit polyclonal to HA tag （FITC）250ug3996HA taghystemcell一抗 Abcam ab12081Goat polyclonal to beta Galactosidase100ug3996beta Galactosidasehystemcell一抗 Abcam ab12083Mouse monoclonal [15F11] to gamma Catenin50ug3996Plakoglobinhystemcell一抗 Abcam ab12085Mouse monoclonal [TLR3.7] to TLR350ug3885TLR3hystemcell一抗 Abcam ab12086Goat polyclonal to SAP102200ug3996SAP102hystemcell一抗 Abcam ab12087Mouse monoclonal [8RB13] to RNA polymerase beta50ul3996RNA polymerase betahystemcell一抗 Abcam ab12088Mouse monoclonal [2G10] to RNA polymerase sigma 7050ul3996RNA polymerase sigma 7hystemcell一抗 Abcam ab12089Mouse monoclonal [1TB18] to TATA binding protein TBP - ChIP Grade50ul3996TATA binding protein TBPhystemcell一抗 Abcam ab1209Rabbit polyclonal to V5 tag （FITC）250ug3996V5 taghystemcell一抗 Abcam ab12090Mouse monoclonal [4Y11] to RNA polymerase II RPB1150ul3996RNA polymerase II RPB11hystemcell一抗 Abcam ab12091Mouse monoclonal [1GFP63] to GFP50ul3996GFPhystemcell一抗 Abcam ab12092Mouse monoclonal [4WG2] to RNA polymerase II RBP850ul3996RNA polymerase II RBP8hystemcell一抗 Abcam ab12093Goat polyclonal to PSD95100ug3996PSD95hystemcell一抗 Abcam ab12094Mouse monoclonal [IIB1] to TFIIB - ChIP Grade50ul3996TFIIBhystemcell一抗 Abcam ab12097Goat polyclonal to PSD93 - Synaptic Marker100ul3996PSD93hystemcell一抗 Abcam ab12098Rabbit polyclonal to Arp8100ug3996Arp8hystemcell一抗 Abcam ab12099Rabbit polyclonal to Arp5250ug3996Arp5hystemcell一抗 Abcam ab12104Rabbit polyclonal to APH1a100ug3996APH1ahystemcell一抗 Abcam ab12107Rabbit polyclonal to Pin1100ug3996Pin1hystemcell一抗 Abcam ab12108Rabbit polyclonal to Glutamate Receptor 1 （AMPA subtype） （phospho T840）100ug3996Glutamate Receptor 1hystemcell一抗 Abcam ab12109Rabbit polyclonal to p40100ug3996p40hystemcell一抗 Abcam ab1211Mouse monoclonal [OX42] to CD11b/c equivalent100ug4418CD11b/chystemcell一抗 Abcam ab12111Rabbit polyclonal to SP150ul3996SP1hystemcell一抗 Abcam ab12112Rabbit polyclonal to STAT4100ul3996STAT4hystemcell一抗 更多詳情，請： 重慶市華雅干細(xì)胞技術(shù)有限公司 |
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