產(chǎn)品信息

Wnt信號(hào)通路是一個(gè)復(fù)雜的蛋白質(zhì)作用網(wǎng)絡(luò)，其功能zui常見(jiàn)于胚胎發(fā)育和癌癥，但也參與成年動(dòng)物的正常生理過(guò)程。Wnt信號(hào)通路包括許多可調(diào)控Wnt信號(hào)分子合成的蛋白質(zhì)，它們與靶細(xì)胞上的受體相互作用，而靶細(xì)胞的生理反應(yīng)則來(lái)源于細(xì)胞和胞外Wnt配體的相互作用。

BIO (6-bromoindirubin-3'-oxime):
a specific GSK3 kinase inhibitor. Inhibition of GSK3-beta results in activation of the canonical WNT pathway leading to the translocation of beta-catenin to the nucleus.

This chemical compound from StemRD is 98.5% pure (HPLC). In a cell-based assay measuring the activation of the TCF reporter gene, this compound gives EC50 of 5.0 micromolar.

Purity:
Greater than 98.5% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.

Biological Activity:
In a cell-based assay measuring the activation of the TCF reporter gene, this compound gives EC50 of 5.0 micromolar.

重慶市華雅干細(xì)胞技術(shù)有限公司